In 2024, multiple drugs received complete response letters (CRLs), sometimes unrelated to the safety and efficacy of the drug ...

M1 receptors, present on the cholinergic ganglia, with the role of facilitating neural transmission; M2 receptors, located on the postganglion endings of the cholinergic fibers, with the role of ...

Defects in the cholinergic signaling pathway have been shown to underlie Alzheimer’s disease and its symptoms.

This treatment is a new class of medication that targets cholinergic receptors instead of dopamine receptors in the brain. The FDA based its approval on the findings of two identical clinical trials.

The company told CBS it will charge around $80 for a 30-day supply of Vuity, a once-daily eyedrop formulation of muscarinic cholinergic agonist pilocarpine intended as an alternative to reading ...

The approval has been granted to Vuity (formerly AGN-190584), a once-daily eyedrop formulation of muscarinic cholinergic agonist pilocarpine developed by AbbVie's Allergen unit that is now an ...

This is an important study using a combination of optogenetics and calcium imaging to provide insight into the function of the cholinergic input to the prelimbic cortex in probabilistic spatial ...

The US Food and Drug Administration approved (xanomeline and trospium chloride) capsules for oral use for the treatment of schizophrenia in adults in September, making it is the first antipsychotic ...

This article examines the existing scientific applicability of the original cholinergic hypothesis of Alzheimer’s disease by describing the biochemical and histopathological changes of ...

Can Heart Heal Itself?A research team co-led by a physician-scientist at the University of Arizona College of Medicine – ...

A variety of antidotes have been reported to treat SSRI-induced sexual dysfunction effectively; however, virtually all the data on these agents are derived from open case reports and case series ...