In 2024, multiple drugs received complete response letters (CRLs), sometimes unrelated to the safety and efficacy of the drug ...

Can Heart Heal Itself?A research team co-led by a physician-scientist at the University of Arizona College of Medicine – ...

The efficacy of individual treatment approaches with contrasting cholinergic and glutamatergic mechanisms of action prompted investigation of the effects of targeting both systems for the ...

Glucagon-like peptide-1 (GLP-1) receptor agonists have quickly become some of the most ubiquitous drugs in the United States. Though they were originally indicated to treat diabetes, and to assist ...

The importance of the brain renin-angiotensin system in cardiovascular function is well accepted. However, not knowing the precise source of renin in the brain has been a limitation toward a complete ...

1Department of Hematology, The First Affiliated Hospital of Xiamen University and Institute of Hematology, School of Medicine, Xiamen University, Xiamen, China. 2Key Laboratory of Xiamen for Diagnosis ...

Startup company Pep2tango Therapeutics Inc., unveiled with backing by Versant Ventures, is advancing unimolecular multireceptor peptide agonists that target GLP-1, GIP, amylin and calcitonin receptors ...

A total of 40 years of biochemical, clinical and neuropathological research have revolutionized our understanding of the pathophysiology of Alzheimer's disease, yet at the present moment the only ...

This month's cover highlights the article A novel bacterial effector protein mediates ER-LD membrane contacts to regulate host lipid droplets by Stacey D. Gilk, Rajendra Angara and Arif Sadi. The ...