Defects in the cholinergic signaling pathway have been shown to underlie Alzheimer’s disease and its symptoms.

Although compounds with a combined cholinergic–glutamatergic action have been trialed, none has yet been successful in the later stages of development (Table 4). Consequently, combination ...

It is also recognised that cholinergic pathways in the cerebral ... The available treatments for the cognitive symptoms of AD are limited. Two cholinesterase inhibitors are available: tacrine ...

For around 70 years, the treatment of schizophrenia has relied almost entirely on drugs that block dopamine receptors, so Cobenfy's action on cholinergic ... help tackle symptoms of schizophrenia ...

Human beings are a bit of a puzzle. There’s a paradoxical desire for connection with others while also staying unique. On the ...

In 2024, multiple drugs received complete response letters (CRLs), sometimes unrelated to the safety and efficacy of the drug ...