Drugs acting on the cholinergic system can improve or worsen cognitive abilities, and their effects are particularly pronounced in frail elderly individuals and patients with Alzheimer disease.

Such studies have resulted in the discovery of an association between a decline in learning and memory, and a deficit in excitatory amino acid (EAA) neurotransmission, together with important roles ...

Although bronchial hyperresponsiveness to cholinergic agents is a main feature of asthma, the role of anticholinergic drugs in chronic asthma management has been largely underestimated. Several ...

Many drugs commonly prescribed to the elderly have anticholinergic properties. Due to the current clinical use of drugs with mild-to-modest anticholinergic activity, the clinical manifestations of ...

This is an important study using a combination of optogenetics and calcium imaging to provide insight into the function of the cholinergic input to the prelimbic cortex in probabilistic spatial ...

The newly approved medicines in 2024 from Massachusetts companies range from a schizophrenia drug to a gene therapy for ...

Summary: Alcohol use disorder (AUD) disrupts cognitive flexibility, crucial for learning and adapting to change. New research ...

In Alzheimer’s disease (AD) there’s a significant atrophy of the basal forebrain cholinergic neurons and losses of synaptic terminations in the cerebral cortex and hippocampus. These neurons depend on ...

Discover groundbreaking research on how chronic alcohol use affects cognitive flexibility and brain signaling circuits, ...

Alcohol use disorder (AUD) affects about 400 million people worldwide and is a leading cause of serious illnesses such as ...

Dec. 19, 2024 — Scientists have unveiled groundbreaking research on the origins of lunar water, offering insights that could reshape our understanding of the Earth-Moon system and the broader ...