为了探究circPIAS1是否可以通过抑制STAT1磷酸化过程来减轻免疫介导的铁死亡，研究人员对肿瘤组织进行了IHC染色分析。ASO-circPIAS1与PD-1抑制剂的联合治疗导致P-STAT1水平显著升高，而GPX4水平则呈相反趋势。此外，研究人 ...

【导读】环状RNA（circRNA）是一种具有共价闭合单链环状结构的调节性RNA。有证据表明，circRNA在多种癌症的进展和发展中发挥着重要作用。然而，circRNA对结直肠癌（CRC）自噬介导的进展的影响尚不明确。

In the rapidly evolving field of genomics, a new class of non-coding RNAs has captured the attention of researchers worldwide - circular RNAs (circRNAs). Unlike their linear counterparts, circRNAs are ...

As fundamental work to clarify their functions, a large number of computational approaches for identifying circRNA formation have been proposed. However, these methods fail to fully utilize the ...

This study aims to bridge this gap by introducing a novel computational model, circRDRP, that enhances prediction accuracy by integrating disease-specific contexts into the analysis of circRNA-drug ...