Alterations in cytokine expression associated with inflammation have long been observed in individuals with immune-mediated disease. Clinical trials carried out almost a decade ago were the first ...
Figure 1. Cytokines involved in acute and chronic inflammatory responses (DOI:10.2741/a171). Image Credit: Sino Biological Inc. Disturbance in levels of the key pro-inflammatory cytokines ...
Unexpected findings now identify multiple secreted inflammatory cytokines, their cognate receptors and positive-feedback loops with corresponding transcription factors, as key mediators of both ...
They could also be the reason why younger people are less affected, as their immune systems are less developed and so produce lower levels of inflammation-driving cytokines. In 2006, six healthy ...