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遗传性基因组不稳定性:导致儿童癌症的风险因素
由于基因组不稳定似乎是儿童癌症发展的主要限速因素,因此可能有机会考虑使用利用细胞DNA损伤反应缺陷的治疗方法。因此,蛋白质抑制剂如共济失调毛细血管扩张和rad3相关蛋白(ATR)、wee1激酶(WEE1)、检查点激酶1 (CHK1)或多聚(ADP-核糖)聚合酶1 ...
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