He explores how flaws in the transcription and DNA repair pathways contribute to cancer predisposition and accelerated aging ...

Mitochondria are vital to energy production in cells and so play a key role in fueling cancer growth. However, how ...

A new study has uncovered how the defense mechanisms of bacteria can be neutralized, facilitating more efficient genetic ...

By inhibiting the DNA polymerases, BKC enhances the endogenous RS in cancer cells, leading to increased DNA damage. IBC specifically inhibits CHK2 to prevent DNA repair. The combined use of BKC and ...

随后研究团队研究发现抑制RF-RDs会导致复制叉新生DNA的降解，并显著增加DNA末端切割和DNA断裂的发生。进一步体外生化实验和细胞实验表明，RF-RDs能够抑制核酸酶DNA2的核酸酶活性，从而减缓DNA2对复制叉的降解。研究团队进一步通过全基因组 ...

A new study by Tel Aviv University reveals how bacterial defense mechanisms can be neutralized, enabling the efficient ...

Smaller nucleoli slow aging, acting as a "mortality timer," while larger nucleoli lead to cell death by destabilizing rDNA. The secret to cellular youth may lie in maintaining a small nucleolus—a ...

Molecular biologists decode the epigenetic silencing of problematic retroviral gene sequences. LMU molecular biologist Gunnar Schotta decodes the epigenetic silencing of problematic retroviral gene ...