Accumulating evidence indicates that epigenetic modifiers have key roles in genome-wide reprogramming and activation and repression of specific genes during mammalian germ-cell development.

In this Review, the functional and molecular consequences of pathological hypoxia on male germ cells and fertility are explored, including potential influences on embryo development and ...

such as the differing types of blood system cells. A second source is embryonic germ cells that are derived from the primordial reproductive tissues of aborted early fetuses. These are the cells ...

Knockout and knock-in mouse lines can be generated using gene targeting in embryonic stem cells with chimera production or CRISPR genome editing in mouse zygotes. For projects involving CRISPR genome ...