Flap endonuclease-1 (FEN-1), a structure specific nuclease, is an essential enzyme for eukaryotic DNA replication and repair. The crystal structure of FEN-1 from Methanococcus jannaschii ...

This study also reveals that endonuclease-competent Argonaute-2 (AGO2) cleaves precursor miRNAs (pre-miRNAs) to produce a new processing intermediate. ...Argonaute proteins post-transcriptionally ...