Third-generation oral contraceptives are an association of low-dose ethinyl estradiol and potent testosterone-derived progestins, developed in order to improve general and vascular tolerance.

Objective and Design: This multicentre, double-blind, randomised, controlled trial evaluated the efficacy of continuous low-dose transdermal estradiol (E 2-TDS) compared with oral conjugated ...

For example, in people with late-onset hypogonadism, lower testosterone levels and an increase of androgens being converted to estradiol is associated with a number of health issues, including: ...