Accumulation of unfolded or mis-folded proteins leads to BIP/GRP78 dissociation from and activation of the ER stress mediators. Generally, the ER stress signalling has a pro-survival function by ...

snu.ac.kr Objective Endoplasmic reticulum (ER) stress is involved in liver injury, but molecular determinants are largely unknown. This study investigated the role of pleckstrin homology-like domain, ...

在即将举行的第75届美国肝病研究学会年会上（AASLD2024），四川大学华西医院的唐红教授团队将揭示一项关于HBV与肝癌发生机制的重要研究。这项研究的核心发现为：HBV可能通过激活GRP78-GLUT1通路，增加宿主细胞的葡萄糖摄取，从而加速肝癌的发生。

As a mechanism of cell death, ferroptosis has gained popularity since 2012. The process is distinguished by iron toxicity and phospholipid accumulation, in contrast to autophagy, apoptosis, and other ...

This package lets you generate entity relation diagrams by inspecting the relationships defined in your model files. It is highly customizable. Behind the scenes, it uses GraphViz to generate the ...

This work describes a circadian regulation in the expression of HERP, a regulator of endoplasmic reticulum calcium, in primary astrocytic cultures. This work is important because it highlights the ...

Stress is a normal reaction. Many times, you can’t avoid it. But you can often lower your stress levels just by taking better care of your body and mind. Want to relax, relieve stress and improve your ...

Like Huggins, many parents are up against the “mother lode” of stress way before the holiday season adds extra demands. What should parents do when even more is piled on for the holidays?

The computer said she was an 88-year-old female with a chief complaint of fatigue. From experience, I knew fatigue in an older person could be caused by almost anything. So … was it a heart attack?

Now, scientists at UC San Francisco are learning how the brain creates these divergent experiences. They hope it will help them find a way to treat those who struggle with long-lasting symptoms of ...