As its name suggests, the fifth histone is associated with the linker DNA that extends between nucleosomal core particles. We will use the name 'linker histone' to include all the closely related ...

They found that tuning of histone H1 levels and chromatin compaction is necessary for response to stress stimuli and that the linker histone H1.0 isoform has a significant role in this process. “We ...

The University of Michigan has identified proteolysis targeting chimeric (PROTACs) compounds comprising cereblon (CRBN) ligands covalently bonded to a CREB-binding protein (CREBBP; CBP) and/or histone ...

Non-condensed nucleosomes without the linker histone resemble "beads on a string of DNA" under an electron microscope. In contrast to most eukaryotic cells, mature sperm cells largely use ...

and tumorigenesis due to its unique linker and macro domains. The histone chaperone Facilitates Chromatin Transcription (FACT) can clear macroH2A from specific locations on the chromatin ...

We capture unwrapping of the DNA near the linker region, thereby facilitating insertion of the catalytic core between the histone octamer and the unwrapped segment of DNA. A network of DNA- and ...

and a series of nucleosomes connected by linker DNAs constitute chromatins. Regulatory proteins can reorganize chromatin structures so that specific genes are transcribed in a spatiotemporal-specific ...

Science 355, 40-45. Claeys Bouuaert C and Keeney S (2017) Distinct DNA-binding surfaces in the ATPase and linker domains of MutLgamma determine its substrate specificities and exert separable ...