USA: A recent secondary analysis of a randomized clinical trial compared chlorthalidone and hydrochlorothiazide to assess their effects on kidney outcomes in patients with hypertension. The findings, ...

In trial 2, 75.8% of patients received valsartan/HCTZ alone over the complete study period. The changes in systolic (SBP) and diastolic (DBP) blood pressure are presented in table II and figure 1.

Lisinopril/HCTZ combination was compared with separate lisinopril and HCTZ tablets. At the end of a year, there was an 18.8% difference in persistence favoring the combination pill. [44] ...