In mammals, autophagosome formation, a central event in autophagy, is initiated by the ULK complex comprising ULK1/2, FIP200, ATG13, and ATG101. However, the structural basis and mechanism of the ULK ...

Long-term, low-dose cannabis treatment has been shown to reverse brain aging and enhance cognitive abilities in mice by modulating the protein switch mTOR, which plays a critical role in cellular ...

Moreover, Rnf144b −/− mice exhibited a higher survival rate upon EMCV infection compared with wild-type mice. The ubiquitin-proteasome and autophagy-lysosome pathways represent the classic protein ...

PDAC tumors are heavily reliant on nutrient-scavenging pathways such as autophagy and the lysosome – a degradative organelle that plays an essential role in the digestion and recycling of diverse ...

Notably, the emergence of SMC-derived luminal myofibroblasts—in both mice and patients with KD, Takayasu’s arteritis and Giant Cell arteritis—coincided with activation of the mechanistic target of ...

These mechanisms may serve as a checkpoint for the presence of the vacuole/lysosome. Animals, fungi and other eukaryotes have cells that are divided into sub-compartments that are called organelles.