Human cell transformation systems revealed that RAL-GEF signaling is particularly required for oncogenic RAS function in human ... Co-opted pathways required by oncogenic KRAS in order to sustain ...

Creation of all things; creation of Adam and Eve; temptation by Satan; Adam and Eve rebel against God and forfeit Garden of Eden. On that day, Adam and Eve, the father and mother of all mankind, chose ...

By inhibiting the DNA polymerases, BKC enhances the endogenous RS in cancer cells, leading to increased DNA damage. IBC specifically inhibits CHK2 to prevent DNA repair. The combined use of BKC and ...