This study describes a valuable new model for in vivo manipulation of microglia, exploring how mutations in the Adar1 gene within microglia contribute to Aicardi-Goutières Syndome. The methodology is ...
IRL-201104 is under clinical development by Revolo Biotherapeutics and currently in Phase I for Inflammation. According to GlobalData, Phase I drugs for Inflammation have a 44% phase transition ...
When exposed to foreign antigens, monocytes (macrophage precursors found in the bloodstream) and macrophages release inflammatory cytokines and sequester and destroy these antigens through ...
2.3. Observation Indexes Statistics of the 1st blood routine results of the study subjects after hospitalization, recording the monocyte count and platelet-related parameters of the experimental and ...
Moreover, XPO1+Epithelial interact with monocytes/macrophages, T/NK cells, and endothelial cells through ligand-receptor pairs, including MIF-(CD74+CXCR4), MIF-(CD74+CD44), and VEGFA-VEGFR1R2, ...