Mazindol ER is under clinical development by NLS Pharmaceutics and currently in Phase II for Narcolepsy. According to GlobalData, Phase II drugs for Narcolepsy have a 59% phase transition success rate ...
For Avadel’s Lumryz, the one-dose extended-release oral suspension that allows narcolepsy patients to sleep through the night, the worst-case scenario is it won't be on the market until 2025 ...
Spiromacrocyclic compounds acting as orexin OX2 receptor agonists have been described in an H. Lundbeck A/S patent and reported to be useful for the treatment of type 1 and type 2 narcolepsy.