Purpose. Published reports on placebo-controlled clinical trials and other studies investigating the use of pure opioid antagonists for the prevention and treatment of opioid-induced pruritus (OIP ...

The increased pressure and/or shearing forces will lead to compression of the pancreatic nerves, and in neurogenic inflammation this results in stimulus-dependent allodynia and hyperalgesia via the ...

22 Visceral hypersensitivity could in principle result from a number of peripheral (eg, mucosal immune activation, mast cell degranulation, altered flora) as well as from central mechanisms. A large ...

From Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville Campus, Victoria, Australia (R.H.R.) Division of Endocrinology and Metabolism (E.D.A.), ...

Enzyme mechanisms are the chemical transformations, and the steps within them, generated by enzymatic action on substrates. The mechanism of enzyme catalysis is similar in principle to other types ...

In addition, some of the excipients used to prepare oral modified-release opioid products, particularly talc, may lead to serious complications if these products are parenterally abused.

Insulin-like growth factor-2 (IGF2), which is widely expressed in the central nervous system (CNS), has emerged as a crucial mechanism of synaptic plasticity and learning and memory, and many studies ...