2018). These knock-in (KI) mice carry a serine to alanine mutation (S65A) in the N-terminal ubiquitin-like domain of the Park2 gene that encodes Parkin, a ubiquitin E3 ligase (McWilliams et al., 2018) ...

The drugs in its preclinical pipeline induce mitophagy and activate a pathway known as the PINK1/Parkin pathway that governs mitochondrial quality control. They bind to an undisclosed, novel target.

In recent years, “pink1,” “apoptosis,” and “Parkinson's disease” clusters have been important research topics in this field with regard to cluster analysis. Dr. Klein, Christine, Dr. Valente, Enza ...

1 Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas Margarita Salas, CSIC, Madrid, Spain 2 Department of Neuroscience and Movement Science, Faculty of Science and ...

Loss of function Parkin mutations lead to early-onset of Parkinson’s disease. Parkin is an auto-inhibited ubiquitin E3 ligase activated by dual phosphorylation of its ubiquitin-like (Ubl) domain and ...

Parkin, PINK1 and DJ-1 operate in the same pathway; they can interact to create an ubiquitin–protein ligase complex. Substrates will need to be identified in stressed cells. Parkin binds to ...

Before joining the Dakota News Now team, Sarah graduated with a Bachelor of Journalism from the College of Journalism and Mass Communications at the University of Nebraska-Lincoln in December of 2019.

Familial cases of PD are often caused by mutations of PTEN-induced kinase 1 (PINK1) and the ubiquitin ligase Parkin, both pivotal in maintaining mitochondrial quality control. CISD1, a homodimeric ...