Smaller nucleoli slow aging, acting as a "mortality timer," while larger nucleoli lead to cell death by destabilizing rDNA. The secret to cellular youth may lie in maintaining a small nucleolus—a ...

The findings are published in the journal Molecular Cell. Ribosomes undergo changes in conformational state, striking ...

Ribosomes undergo changes in conformational state, striking different, well-orchestrated poses that allow strands of RNA to be fed through the structure's two subunits where instructions carried ...

RNA-targeting compounds or small interfering RNAs (siRNAs) offer a potent means for controlling viral infections. An essential prerequisite to their design depends on identifying conserved and ...

This work introduces an important new method for depleting ribosomal RNA from bacterial single-cell RNA sequencing libraries, demonstrating its applicability for studying heterogeneity in microbial ...

These molecular signatures, unique to different tissues and altered in cancer, could potentially identify tumors using just a tiny sample of tissue and a portable device no bigger than the palm of ...

Ribosomes are made of proteins and a special type of RNA molecule called ribosomal RNA (rRNA). rRNA molecules are the target of chemical modifications, affecting the ribosome’s function.