Hyperglycemia, a state of metabolic dysregulation, can induce stress in the endoplasmic reticulum, an organelle crucial for protein synthesis, folding, and transport. Under stress, it releases calcium ...

A man who caused an online storm when he found a Mars bar without its signature ripple has received £2 in compensation. Harry Seager’s picture of the confectionery generated interest from ...

Inside cells, there exists an extensive system of canals known as the endoplasmic reticulum (ER), which consists of membrane-encased tubes that are partially broken down as needed – for instance in ...

Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan ...

This work explores the physical principles underlying fluid flow and luminal transport within the endoplasmic reticulum. Its important contribution is to highlight the strong physical constraints ...

Currently, all of the identified degrons only function within the cytosol. Using Saccharomyces cerevisiae, we identified the first short linear sequences that function as degrons from the endoplasmic ...

Cancer is a multifactorial disease characterized by complex molecular landscape and altered cell pathways that results in an abnormal cell growth. Natural compounds are target-specific and pose a ...