Here we look back at one of its key reactions: strain-promoted azide–alkyne cycloadditions (SPAAC). Owing to its robustness, simplicity and applicability to living systems, SPAAC continues to ...

信使核糖核酸(messenger ribonucleic acid, mRNA)是一种极具潜力的治疗药物, 在免疫学、肿瘤学、疫苗和先天性代谢疾病等研究领域具有广阔前景。但由于其自身不稳定且易被核酸酶降解所以需要高效的递送载体。脂质纳米颗粒(lipid nanoparticle, LNP)具有易于配制、稳定性高 ...

Biocatalysts have many benefits for speeding up specific transformations, but the chemistry used by naturally occurring catalysts is limited. Pioneering work in 2016 used directed evolution to ...

School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China Institute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen 518132, China ...