This study provides important insights into the regulation of a retained intron in the mRNA coding for OGT, a process known to be regulated by the O-GlcNAc cycling system, and highlights the ...

Cell and gene therapies are revolutionizing medicine. Looking to 2025, advancements in allogeneic therapies, streamlined ...

When the site selection occurs within the last exon of a gene (a DNA sequence ... “A simple way to explain it is if you have a longer transcript produced by a gene, that longer transcript ...

Del-brax (AOC 1020) for FSHD showed a 50% reduction in DUX4 gene expression ... marking a promising advancement for exon 44 skipping therapies. I reiterate my “Strong Buy” due to its pipeline ...

President-elect Donald Trump, welcome back to Meet the Press. PRESIDENT-ELECT DONALD TRUMP: Thank you very much. KRISTEN WELKER: Thank you so much for being here. You are the first president since ...

"In synthetic biology or gene therapy, transcription factors with off-target effects can cause some concerning unintended consequences, so, by understanding and being able to manipulate mechanisms ...

For example, an sQTL of the TCHP gene has been identified ... the high average sequencing depth and the "exon painting" effect (incomplete reverse transcription along with stochastic mRNA cleavage ...

2024) Pluripotency is thought to have emerged with the appearance of multicellular animals some 700 million years ago, so it stands to reason that transcription factors associated with stem cell ...