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Sci Adv:线粒体DNA在白血病发生过程中或扮演着被低估的重要角色
这种效应或许与白血病细胞重编程其代谢从而在恶劣的肿瘤微环境中茁壮成长(其可塑性)有关,而来自mtDNA突变的代谢压力或许也会增加细胞的可塑性。因此,当杂合子小鼠暴露于一点代谢压力时就会增加对不同癌基因转化的易感性,而在纯合子小鼠中,其基本上是关闭的, ...
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