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21 小时
前列腺癌抗雄激素耐药性新机制:中科院高栋团队揭示LKB1失活的双重 ...
【导读】在阉割耐药前列腺癌(CRPC)中,雄激素受体(AR)依赖性细胞系可塑性背后的复杂性仍不清楚,导致有效的临床治疗方法匮乏。团队利用人类和小鼠前列腺癌样本的单细胞RNA测序,结合全基因组亚硫酸氢盐测序和多种基因工程小鼠模型,研究了AR依赖性血统可 ...
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