Do the findings shut the door on approaches to increase fatty acid oxidation ... 1 find no benefit from quelling the activity of acetyl-CoA carboxylase-2 (ACC-2), an enzyme downstream of AMPK ...

Dr. Wakil demonstrated the requirement of ATP and stimulatory effect of carbon dioxide on fatty acid synthesis from acetyl-CoA, and showed that long-chain fatty acids are synthesized by a system ...

For some time, our work has focused on understanding the roles of acetyl-CoA carboxylases, ACC1 and ACC2, in the regulation of fatty acid synthesis and oxidation as related to energy homeostasis. Our ...