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腾讯网
24d
Cell Metab | 黄志锋/宋林涛/李校堃团队发现胆汁淤积症治疗新靶点
胆汁酸(Bile acid, BA)稳态对于各种生理过程至关重要,其紊乱则会引起肝损伤、胆汁淤积症,严重者可诱发肝癌。法尼醇X受体(FXR)是胆汁酸稳态 ...
腾讯网
7d
《细胞》新突破:难忍的浑身瘙痒,终于有救了!雷晓光/李毓龙/陈煜团队合作揭示胆汁淤积瘙痒的分子机制
皮肤没长什么东西,却莫名其妙地反复瘙痒,在夜晚格外严重,甚至痒得睡不着觉;身上挠出一道道印子,用了很多护肤品 ...
生物谷
23d
Cell Metab:黄志锋/宋林涛/李校堃团队发现胆汁淤积症治疗新靶点
本研究鉴定了肝脏FGF4作为FXR的直接转录靶基因,也是外周FGF15/19通路上游以肝脏为中心的胆汁酸合成反馈抑制因子。 温州医科 ...
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