Altered target enzymes (increased dihydrofolate reductase activity or expression, kinetically altered dihydrofolate reductase, increased 5-aminoimidazole-4-carboxamide ribonucleotide ...

Methotrexate sodium tablets are a dihydrofolate reductase inhibitor indicated for the: Treatment of adults with acute lymphoblastic leukemia (ALL) as part of a combination chemotherapy maintenance ...

Ibrilatazar is under clinical development by Ability Pharmaceuticals and currently in Phase III for Metastatic Pancreatic Cancer.

Renal Blood urea nitrogen or creatinine at least twice the upper limit of normal for laboratory or urinary sediment with pyuria (≥5 leukocytes per high-power field) in the absence of urinary ...

In conclusion, we would like to emphasize two points: first, the importance of the cis conformation of peptide bonds in protein structures, especially if it is a Xaa–nonPro peptide bond, and ...

Department of Molecular, Cell and Systems Biology, University of California Riverside, Riverside, USA Stowers Institute for Medical Research, Kansas City, USA ...

Introduction: Dengue Fever continues to pose a global threat due to the widespread distribution of its vector mosquitoes, Aedes aegypti and Aedes albopictus. While the WHO-approved vaccine, Dengvaxia, ...

In 2023, 10.8 million people fell ill with tuberculosis (TB) with an estimated 1.25 million deaths globally. While 400,000 people were diagnosed with multi-drug resistant (MDR) and/or ...