Current treatments for premature ejaculation lose efficacy over time (because of behavior modification), have adverse effects (penile anesthesia) or must be used with a condom (topical creams).
Key efficacy and safety recommendations were as ... is statistically significant," or "The proportion of subjects who lose greater than or equal to 5% of baseline body weight in the active-product ...
“The monoclonal antibody will lose its efficacy eventually, but it may also potentially create the hazard of escape mutants that will perpetuate the pandemic or endemic infection.” SAB ...