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酶标仪高端玩家指南: 高通量LNP表观pKa测定
随着 COVID-19 mRNA 疫苗的成功应用,LNPs 的研究和开发获得了前所未有的关注。这其中,精确测定 LNPs 的表观 pKa 值对于优化其递送效率和安全性至关重要。 什么是 LNPs 的表观 pKa? 酸解离常数 (pKa) 的定义是体系中电离(质子化)基团和非电离基团数目相等时的 pH ...
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