Objective The microbiome contributes to the pathogenesis of inflammatory bowel disease (IBD) but the relative contribution of different lifestyle and environmental factors to the compositional ...

Background Over a century ago, Virchow proposed that cancer represents a chronically inflamed, poorly healing wound. Normal ...

Correspondence to Dr Richard C Pollok, Gastroenterology, St George's University Hospitals NHS Foundation Trust, London SW17 0QT, UK; richard.pollok{at}nhs.net Objective Depression is a potential risk ...

Objective Early-onset colorectal cancer (CRC) is increasing in the USA despite rapid declines in older ages. Similar patterns are reported in Australia and Canada, but a comprehensive global analysis ...

Introduction Odynophagia can be defined as a painful sensation in the oesophageal region that occurs in relation to swallowing. Unlike dysphagia, which has historically been an alarm symptom or ...

Objective Dietary fibres are essential for maintaining microbial diversity and the gut microbiota can modulate host physiology by metabolising the fibres. Here, we investigated whether the soluble ...

Objective The epithelial layer of the GI tract is equipped with innate immune receptors to sense invading pathogens. Dysregulation in innate immune signalling pathways is associated with severe ...

Introduction Alcohol use disorders and alcohol related liver disease have a significant adverse impact on individuals, healthcare and society. Although abstinence is highly effective, engagement with ...

Correspondence to Dr Jonathan Hoare, Department of Gastroenterology, Imperial College Healthcare NHS Trust, London, UK; j.hoare{at}ic.ac.uk This is the first UK national guideline to concentrate on ...

Correspondence to: K R Palmer, Western General Hospital, Crewe Rd, Edinburgh, EH4 2XU, UK; kpalmer{at}golf5063.freeserve.co.uk “Medline” and “EMBASE” were searched to identify the evidence used in ...

Objective The HBV HBx regulatory protein is required for transcription from the covalently closed circular DNA (cccDNA) minichromosome and affects the epigenetic control of both viral and host ...

Objective Effects of the diet-induced gut microbiota dysbiosis reach far beyond the gut. We aim to uncover the direct evidence involving the gut–testis axis in the aetiology of impaired ...