Discover groundbreaking research on how chronic alcohol use affects cognitive flexibility and brain signaling circuits, ...

Researchers have uncovered important insights that could improve how mental health conditions are treated with brain stimulation therapy -- a treatment where electrical signals are used to stimulate ...

Alcohol use disorder (AUD) affects about 400 million people worldwide and is a leading cause of serious illnesses such as ...

Spiny projection neurons (SPNs) in dorsal striatum are often proposed as a locus of reinforcement learning in the basal ganglia. Here, we identify and resolve a fundamental inconsistency between ...

Weaknesses: A weakness in this work is that it isn't clear how a key component in the model - an efferent copy of selected actions - would be accessible to these striatal populations. The authors ...

The limited efficacy could be due to regional differences in the dysregulation of the dopamine system. This study investigated striatal and peripheral dopaminergic makers in schizophrenia and their ...

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