TX45 was well-tolerated with no observed immunogenicity, and demonstrated a favorable PK/PD relationship which was used to identify doses for the ...

In normal human physiology, relaxin is upregulated during pregnancy where it exerts vasodilative effects, reduces systemic and pulmonary vascular resistance and increases cardiac output to ...

but also the effects of vasodilative combination therapy to improve the overall outcome in the patients with SSc. S. Lambova declares an association with the European League Against Rheumatism.

WATERTOWN, Mass., Sept. 19, 2024 (GLOBE NEWSWIRE) -- Tectonic Therapeutic, Inc. (NASDAQ: TECX) (Tectonic), a clinical stage biotechnology company focused on the discovery and development of ...

TX45, an Fc-relaxin fusion protein targeting the RXFP1 receptor, is designed to mimic the vasodilative and anti-fibrotic effects of the hormone relaxin. The Phase 1a trial assessed single ...

TX45, an Fc-relaxin fusion protein targeting the RXFP1 receptor, is designed to mimic the vasodilative and anti-fibrotic effects of the hormone relaxin. The Phase 1a trial assessed single ascending ...