Conquering the cytokine storm in COVID‐19‐induced ARDS …
2021年10月10日 · Acute respiratory distress syndrome (ARDS) is the most common cause of death in COVID‐19 patients. The cytokine storm is the main driver of the severity and magnitude of ARDS. Placenta‐derived decidua stromal cells (DSCs) have a stronger immunosuppressive effect than other sources of mesenchymal stromal cells.
Frontiers | Cytokine Storm: The Primary Determinant for the ...
2021年4月27日 · Among them, the cytokine storm caused by SARS-CoV-2 is the key reason for deterioration within a short time-span in COVID-19 patients and subsequent development into acute respiratory distress syndrome (ARDS), leading to respiratory failure and eventual death from multiple organ failure.
COVID-19 infection: an overview on cytokine storm and related ...
2022年5月26日 · ARDS is one of the leading causes of death in patients with COVID-19 and is mainly triggered by elevated levels of pro-inflammatory cytokines, referred to as cytokine storm. Interleukins, such as interleukin-6 (1L-6), interleukin-1 (IL-1), interleukin-17 (IL-17), and tumor necrosis factor-alpha (TNF-α) play a very significant role in lung ...
The pathogenesis and treatment of the `Cytokine Storm' in …
Cytokine storm causes ARDS or multiple-organ dysfunction, which leads to physiological deterioration and death. Timely control of the cytokine storm in its early stage through such means as immunomodulators and cytokine antagonists, as well as the reduction of lung inflammatory cell infiltration, is the key to improving the treatment success ...
Specific cytokines in the inflammatory cytokine storm of patients …
2021年6月4日 · ARDS is a product of the inflammatory cytokine storm following SARS-CoV-2 infection, and also exacerbates the inflammatory cytokine storm. Therefore, effective inhibition of the inflammatory cytokine storm during the early stages of COVID-19 may be an effective therapeutic strategy to prevent the development of ARDS, alleviate extrapulmonary ...
Progress in cytokine research for ARDS: A comprehensive review
2024年10月28日 · Results: Pro-inflammatory cytokines are crucial in initiating inflammatory responses and lung injury in early ARDS, while anti-inflammatory cytokines help regulate and resolve inflammation. Targeted therapies, such as IL-1 and IL-6 inhibitors, show potential in managing ARDS, particularly in COVID-19, but their clinical efficacy is still debated.
The Potential Role of Cytokine Storm Pathway in the Clinical
2021年11月15日 · The excessive local release of cytokines is considered to be the determinant of pathological alterations and the clinical manifestation of acute respiratory distress syndrome (ARDS). SARS-CoV-2 infection triggers an immune response producing inflammatory cytokines along with a weak response to interferon (IFN).
The cytokine storm in COVID-19: An overview of the involvement …
2020年6月1日 · COVID-19 pandemic is raging worldwide and is putting health-care systems under severe strain. The “cytokine storm” and the subsequent ARDS result from the effects of the combination of several immune-active molecules. The “cytokine storm” is the most dangerous and potentially life-threatening event related to COVID-19.
N-acetyl-cysteine may prevent COVID-19-associated cytokine storm …
2020年4月22日 · Accumulating evidence suggests that a subgroup of patients with severe COVID-19 might have a cytokine storm syndrome associated with acute respiratory distress syndrome (ARDS), multiple organ failure and increased mortality.
The critical impacts of cytokine storms in respiratory disorders
2024年5月15日 · Cytokine storm (CS) inflicts severe damage to pulmonary tissue, potentially progressing to Acute Respiratory Distress Syndrome (ARDS), representing the most devastating consequence of CS [[17], [148], [149]]. Immediate CS treatment is imperative to prevent ARDS, as a lack of adequate medication may result in multiple organ dysfunctions and ...