Fructose contributes to the Warburg effect for cancer growth
2020年7月10日 · Clinical and experimental evidence showed that fructose intake was associated with cancer growth and that fructose transporters are upregulated in various malignant tumors. Interestingly, fructose metabolism can be driven under low oxygen conditions, accelerates glucose utilization, and exhibits distinct effects as compared to glucose ...
Exploring fructose metabolism as a potential therapeutic ... - Nature
2024年10月15日 · Fructose exacerbates the growth and progression of pancreatic cancer. To determine whether fructose serves as an energy source for pancreatic cancer cells, we conducted a study using human ...
AKR1B1-dependent fructose metabolism enhances malignancy of cancer …
2024年10月15日 · Fructose metabolism has emerged as a significant contributor to cancer cell proliferation, yet the underlying mechanisms and sources of fructose for cancer cells remain incompletely understood....
Dietary Fructose and Fructose-Induced Pathologies - PMC
2022年8月8日 · While these findings suggest direct fructose utilization by cancer cells, the question remains whether a sufficient amount of fructose is present in the circulation or in the tumor microenvironment. Mounting experimental evidence indicates that increased fructose consumption can trigger tumor formation, progression, and metastasis.
Fructose Metabolism in Cancer - PubMed
2020年12月8日 · We describe the different metabolic fates of fructose carbons and how they are connected to lipogenesis and nucleotide synthesis. In addition, we discuss how the endogenous production of fructose from glucose via the polyol pathway can be beneficial for cancer cells.
Increased utilization of fructose has a positive effect on the ...
2017年9月27日 · Our findings review the relationship between increased dietary fructose and breast cancer risk, and provide important insights into recent epidemiological studies and present preliminary insights into the potential therapeutic strategies …
Fructose sweetens the adipocyte-T cell alliance against tumors
2023年12月5日 · This intricate interplay between dietary fructose, adipocyte-derived leptin, and CD8 + T cells unveils a new dimension in our understanding of how diet and immunity intersect in the context of cancer, opening promising avenues for further development of cancer immunotherapy.
Fructose-induced metabolic reprogramming of cancer cells
2024年4月21日 · Overall, these studies have demonstrated that cancer cells that reside in organs that directly metabolize fructose, such as the liver and intestine, can undergo reprogramming and utilize fructose to support its metabolic needs.
High dietary fructose promotes hepatocellular carcinoma …
2023年11月7日 · Emerging studies have addressed the tumor-promoting role of fructose in different cancers. The effects and pathological mechanisms of high dietary fructose on hepatocellular carcinoma (HCC) remain unclear.
Fructose and prostate cancer: toward an integrated view of
2018年8月13日 · This review examines the role of fructose uptake and metabolism in cancer, with special emphasis on prostate cancer, and how fructose uptake and metabolism integrate with glycolytic and ...