Uroporphyrinogen - Wikipedia
Uroporphyrinogens are cyclic tetrapyrroles with four propionic acid groups ("P" groups) and four acetic acid groups ("A" groups). There are four forms, which vary based upon the arrangements of the "P" and "A" groups (in clockwise order): In the "I" variety (i.e. uroporphyrinogen I), the order repeats four times: AP-AP-AP-AP.
Biochemistry, Uroporphyrinogen - StatPearls - NCBI Bookshelf
2023年7月17日 · Uroporphyrinogens are cyclic tetrapyrroles (four pyrroles connected in a ring structure by methylene or methine bridges) with four propionic acid (P) groups and four acetic acid (A) groups. The various uroporphyrinogens differ by their arrangement of the side groups.
Uroporphyrinogen - an overview | ScienceDirect Topics
Uroporphyrinogen is a compound involved in the biosynthesis of siroheme, serving as a prosthetic group for certain enzymes. It undergoes a unique C-methylation process within the tetrapyrrole uroporphyrinogen III, distinct from heme and chlorophyll pathways. You might find these chapters and articles relevant to this topic.
Uroporphyrinogen III - Wikipedia
Uroporphyrinogen III is a tetrapyrrole, the first macrocyclic intermediate in the biosynthesis of heme, chlorophyll, vitamin B12, and siroheme. It is a colorless compound, like other porphyrinogens .
血红素的生物合成：四个吡咯环如何连到一起 - 知乎
金属卟啉（Metalloporphyrin）是生物中广泛存在的一类化合物。 其中，血红素（铁原卟啉IX）是分布最广泛的一种。 一些含血红素的蛋白作为信号转导蛋白参与生理活动的调控。 血红素生物合成起始于 甘氨酸 和 琥珀酰辅酶A。 甘氨酸 脱羧并和 琥珀酰辅酶A 缩合形成 5-氨基乙酰丙酸 （又称δ-氨基-γ-酮戊酸，δ-aminolevulinic acid， ALA）。 这步反应由 ALA合成酶 催化，辅酶是磷酸吡哆醛（维生素B6）。 然后 ALA脱水酶 催化两分子 ALA 脱去两分子水，形成 胆色素原 （又称 …
Uroporphyrinogen III - an overview | ScienceDirect Topics
Uroporphyrinogen III is a truly versatile intermediate since all other tetrapyrrole biosynthetic pathways originate from its template. If the acetic acid side chains are decarboxylated to coproporphyrinogen III, uroporphyrinogen III follows the heme synthesis pathway.
Uroporphyrinogen - an overview | ScienceDirect Topics
Human uroporphyrinogen synthase is a monomeric bilobed structure in which the two domains are attached by a two-strand antiparallel β-sheet. The few residues that are conserved in uroporphyrinogen synthases correspond to an area within a large open cleft between the two domains, which likely contains the active site.
Biochemistry, Uroporphyrinogen - PubMed
2023年7月17日 · Uroporphyrinogens are porphyrinogens that also contain a propionic acid ("P" group) and acetic acid ("A" group) side group connected to each pyrrole in the macrocyclic core (8 side groups in total, 4 Ps and 4 As).
Uroporphyrinogen I synthase and uroporphyrinogen III cosynthase
Uroporphyrinogen I synthase and uroporphyrinogen III cosynthase. Production of uroporphyrin III requires two enzymes. The substrates are four molecules of porphobilinogen. The first reaction is catalyzed by uroporphyrinogen I synthase. The porphobilinogen molecules …
Biosynthesis of uroporphyrinogens from porphobilinogen: mechanism and ...
1976年2月5日 · The enzymic self-polymerization of prophobilinogen gives rise to the cyclic tetrapyrroles uroporphyrinogen III and uroporphyrinogen I. The former is the precursor of all the natural porphyrins and chlorins. The formation of uroporphyrinogen III is catalysed by a dual enzymic system, porphobilinogen deaminase and uroporphyrinogen III cosynthase.
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