Direct control of lysosomal catabolic activity by mTORC1 through ...
网页2022年8月17日 — Here, we show that mTORC1 blocks lysosomal degradation of extracellular proteins by suppressing V-ATPase-mediated acidification of lysosomes. When mTORC1 is active, peripheral V-ATPase V 1...
mTOR and lysosome regulation - PMC - National Center for …
网页2014年7月8日 — Recent evidence suggests that mTORC1 serves as a negative regulator of lysosomal function. Zhou and colleagues compared lysosomal function between fed and starved cells by measuring lysosomal acidification, cathepsin activity, and rate of …
Spatial and functional separation of mTORC1 signalling in ... - Nature
网页3 天之前 — a,b, mTOR/LAMP2 colocalization (a) and its quantification (b). mTOR delocalizes away from lysosomes already after 2 h of BafA1 treatment. Time course of BafA1 treatment (100 nM, 2–8 h) to block ...
mTOR and lysosome regulation - PubMed
网页2014年7月8日 — Lysosomes are key cellular organelles that play a crucial role in catabolism by degrading extracellular and intracellular material. It is, therefore, very intriguing that mTORC1 (mechanistic target of rapamycin complex 1), a major promoter of anabolic processes, localizes in its active form to the surface of lysosomes.
mTORC1 regulates a lysosome-dependent adaptive shift in
网页2022年12月19日 — Distinct from the established role of mTORC1 activation in promoting de novo lipid synthesis, our data indicate that mTORC1 inhibition triggers membrane phospholipid trafficking to the lysosome...
Amino acid-dependent control of mTORC1 signaling: a variety of ...
网页2020年8月17日 — mTORC1 regulates cell growth and metabolism by modulating protein, lipid, and purine synthesis, as well as lysosome biogenesis and autophagy (Fig. 1 b). mTORC1 activity is influenced by a variety of signals such as amino acids, glucose, growth factors, energy levels, and stresses [2, 12, 13, 14, 15, 16, 17, 18].
Non-canonical mTORC1 signaling at the lysosome - Cell Press
网页2022年5月30日 — Non-canonical mTORC1 signaling responds to stimuli that converge on the lysosomal surface. Rag GTPases mediate a novel mTORC1 substrate-recruitment mechanism. Deregulation of non-canonical mTORC1 signaling underlies the pathogenesis of different types of inherited diseases and cancer.
The lysosome: a crucial hub for AMPK and mTORC1 signalling
网页2017年4月13日 — Much is now understood about how the lysosome contributes to amino acid sensing by mTORC1, the involvement of the energy-sensing kinase, AMP-activated protein kinase (AMPK), at the lysosome and how both AMPK and mTORC1 signalling pathways feedback to lysosomal biogenesis and regeneration following autophagy.
Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent ... - PubMed
网页2017年11月10日 — Inhibition of mTOR strongly reduced the lysosomal efflux of most essential amino acids, converting the lysosome into a cellular depot for them. These results reveal the dynamic nature of lysosomal metabolites and that V-ATPase- and mTOR-dependent mechanisms exist for controlling lysosomal amino acid efflux.
Lysosomal metabolomics reveals V-ATPase- and mTOR …
网页2017年10月26日 — Inhibition of mTOR strongly reduced the lysosomal efflux of most essential amino acids, converting the lysosome into a cellular depot for them. These results reveal the dynamic nature of lysosomal metabolites and that V-ATPase- and mTOR-dependent mechanisms exist for controlling lysosomal amino acid efflux.
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