Monocrotaline - Wikipedia
Monocrotaline (MCT) is a pyrrolizidine alkaloid that is present in plants of the Crotalaria genus. These species can synthesise MCT out of amino acids and can cause liver, lung and kidney damage in various organisms.
Monocrotaline (Crotaline，野百合碱) - 仅供科研 | 吡咯里西啶生 …
Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid. Monocrotaline inhibits OCT-1 and OCT-2 with IC 50 s of 36.8 µM and 1.8 mM, respectively. Monocrotaline has antitumor activity and is cytotoxic to hepatocellular carcinoma cells. Monocrotaline is used to induce a model of pulmonary hypertension in rodents. .
Monocrotaline | C16H23NO6 | CID 9415 - PubChem
Monocrotaline is bioactivated by the liver to a reactive, electrophilic pyrrole that travels via the circulation to the lung, where injury results. When low, iv doses of monocrotaline pyrrole are given to rats, a delay of several days occurs before lung injury and pulmonary hypertension become apparent.
Monocrotaline Induces Endothelial Injury and Pulmonary Hypertension …
2017年3月27日 · Monocrotaline has been widely used to establish an animal model of pulmonary hypertension. The molecular target underlying monocrotaline‐induced pulmonary artery endothelial injury and pulmonary hypertension remains unknown. The extracellular calcium–sensing receptor (CaSR) and particularly its extracellular domain hold the potential ...
Monocrotaline - SpringerLink
2018年11月20日 · Monocrotaline is a pyrrolizidine alkaloid which has anticancer and anti-choline effects. In vitro study suggested that monocrotaline has significant cytotoxicity in human BEL-7402, KB cancer cells through inducing DNA alkylation . Monocrotaline’s toxicity is low, but its metabolites in the liver have high liver toxicity.
Monocrotaline Induces Endothelial Injury and Pulmonary …
2017年3月27日 · Monocrotaline aggregates on and activates the CaSR of pulmonary artery endothelial cells to trigger endothelial damage and, ultimately, induces pulmonary hypertension. Keywords: endothelial injury, extracellular calcium–sensing receptor, intracellular calcium, monocrotaline, pulmonary hypertension.
Monocrotaline - an overview | ScienceDirect Topics
Monocrotaline (MCT) is a phytotoxin derived from the seeds of Crotalaria spectabilis and is in vivo activated by mixed-function oxidases in the liver to form the reactive bifunctional cross-linking compound MCT pyrrole. MCT has a selective toxic effect on pulmonary vessels without an effect on systemic vessels because the lungs represent the ...
Early progression of pulmonary hypertension in the monocrotaline …
Lung edema in males treated with MCT. Lung weight normalized on the bodyweight showed a significant increase in males due to liquid accumulation in the lungs and indicated lung edema (a).Histology showed the formation of perivascular cuffs pronounced in male rats treated with monocrotaline (arrows) (b).Quantification of vessel wall thickness shows a significant increase in males (c) mean ± ...
Endothelial cell ferroptosis mediates monocrotaline-induced …
2022年2月23日 · Pulmonary artery endothelial cells (PAECs) and lung tissues from monocrotaline (MCT)-induced PH rats were analysed for ferroptosis markers, including lipid peroxidation, the labile iron pool...
Inflammation Intensifies Monocrotaline-Induced Liver Injury
2023年2月8日 · Monocrotaline (MCT) is a pyrrolizidine alkaloid from the plants of Crotalaria genus that causes hepatic and cardiopulmonary toxicities, and the exhibition of the toxicities requires the metabolic activation by CYP3A4 to form electrophilic dehydro-monocrotaline (DHM). The present study demonstrated that myeloperoxidase (MPO) also participated in ...