Aldolase B - Wikipedia
Mechanism. The aldol cleavage of fructose 1,6-bisphosphate by aldolase b demonstrates the different reaction products, dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. The generic fructose bisphosphate aldolase enzyme cleaves a 6-carbon fructose sugar into two 3-carbon products in a reverse aldol reaction.
12.4: Aldol Addition - Chemistry LibreTexts
2022年7月20日 · The enzymes that catalyze aldol reactions are called, not surprisingly, aldolases. Note that the aldol reaction results in a product in which a hydroxide group is two carbons away from the carbonyl, in the β β position. You can think of the β β -hydroxy group as a kind of 'signature' for an aldol addition product.
Aldolase is a sensor for both low and high glucose, linking to
2020年12月21日 · a Schematic diagram of catalytic mechanisms of aldolase. 8 b–e Expression of the D34S aldolase mutant retains mTORC1 activity in low glucose, while the K230A mutant inhibits mTORC1 even in...
Aldolase is a sensor for both low and high glucose, linking to …
2020年12月21日 · Aldolase is a sensor of glucose availability for mTORC1 regulation. a Schematic diagram of catalytic mechanisms of aldolase. 8 b–e Expression of the D34S aldolase mutant retains mTORC1 activity in low glucose
Aldolase - an overview | ScienceDirect Topics
Aldolase is one of the principal glycolytic enzymes that catalyze the conversion of d-fructose-1,6-diphosphate to dihydroxyacetone phosphate and d-glyceraldehyde-3-phosphate. There are three cytosolic isoenzymes: aldolase A, which predominates in muscle; …
Aldolase B suppresses hepatocellular carcinogenesis by ... - Nature
2020年7月6日 · Here we show that hepatic aldolase B (Aldob) suppresses HCC by directly binding and inhibiting the rate-limiting enzyme in the pentose phosphate pathway, glucose-6-phosphate dehydrogenase...
Biochemistry, Fructose Metabolism - StatPearls - NCBI Bookshelf
2022年10月17日 · Aldolase B is the predominant form of aldolase in proximal renal tubules. The interaction between aldolase B and vacuolar type-ATPase (V-ATPase) is critical for the proximal renal tubules for proper acidification function regarding proton transport across the tubules and endosomal acidification.
Aldolase: A Desirable Biocatalytic Candidate for ... - MDPI
2023年12月13日 · This figure illustrates the catalytic mechanisms of three aldolase isomers in the breakdown of glucose and fructose during glycolysis and fructolysis. The process results in the formation of fructose 1,6-phosphate and fructose 1-phosphate.
Aldolase B - an overview | ScienceDirect Topics
Aldolase B catalyzes the reversible cleavage of fructose-1-phosphate to form dihydroxyacetone phosphate and D-glyceraldehyde. From: Genetic Diseases of the Kidney, 2009
Fructose-1,6-bisphosphate and aldolase mediate glucose sensing …
2017年7月19日 · Here, we describe an AMP/ADP-independent mechanism that triggers AMPK activation by sensing the absence of fructose-1,6-bisphosphate (FBP), with AMPK being progressively activated as...