Dynamin-dependent vesicle twist at the final stage of clathrin ... - Nature
2021年7月12日 · Dynamin has an important role in clathrin-mediated endocytosis by cutting the neck of nascent vesicles from the cell membrane.
Role of Clathrin and Dynamin in Clathrin Mediated …
2022年1月18日 · This work describes the structure and function of dynamin and clathrin in endocytosis across clathrin mediated and synaptic vesicle endocytosis; the potential role of SVE in neurological diseases and the current state of the art in developing CME (and SVE) inhibitors via targeting of dynamin and clathrin.
Mechanisms of clathrin-mediated endocytosis - Nature
2018年2月7日 · In canonical clathrin-mediated endocytosis, this step is catalysed by the large GTPase dynamin, which assembles into a helical collar at the neck of the clathrin-coated pit and breaks it.
Dynamin, a membrane-remodelling GTPase - Nature
2012年1月11日 · The role of dynamin is best defined during clathrin-dependent endocytosis and is essential only for a late step when membrane fission occurs. Gene-knockout studies in mice and the cells derived...
The Structural Biology of the Dynamin-Related Proteins: New …
Dynamin-related proteins are multidomain, mechanochemical GTPases that self-assemble and orchestrate a wide array of cellular processes. Over the past decade, structural insights from X-ray crystallography and cryo-electron microscopy have reshaped our mechanistic understanding of these proteins.
Molecular Structure, Function, and Dynamics of Clathrin …
Another, less-direct link between clathrin and actin is through dynamin, which can bind cortactin, an activator of Arp2/3 (Merrifield et al. 2005; Taylor et al. 2012). Once uncoated, previously clathrin-coated vesicles can engage actin and move rapidly away from the site at which they formed ( Merrifield et al. 2002 ).
Dissecting dynamin's role in clathrin-mediated endocytosis
Recent evidence derived from divergent in vivo and in vitro approaches suggests that dynamin plays a dual role in CME, functioning at early stages as a fidelity monitor to regulate clathrin-coated pit maturation and at later stages to directly catalyse membrane fission and clathrin-coated vesicle formation.
发动蛋白及其蛋白超家族的功能 - pibb.ac.cn
Classical dynamins are primarily involved in clathrin-mediated endocytosis (CME), a process crucial for the internalization of receptors and other membrane components from the cell surface into the cell. These proteins are best known for their …
Demystifying Dynamics of Dynamin During Clathrin Mediated …
2020年2月7日 · Using this method, we have visualized the dynamics of cargo induced by dynamin towards the end of clathrin mediated endocytosis (CME), which will finally complete our understanding on the mechanisms of dynamin scission in CME in live cells.
Functional recruitment of dynamin requires multimeric ... - Nature
2019年10月1日 · During clathrin mediated endocytosis (CME), membrane scission is achieved by the concerted action of dynamin and its interacting partners such as amphiphysins. Here authors show that efficient...