Galactosylation - an overview | ScienceDirect Topics
In most cases, the α-anomer of mono-galactosylated ceramides can be easily separated from the β-one by column chromatography. In addition, galactosylation reaction of a ceramide proceeds kinetically with high α-selectivity, and a sufficient amount of …
Galactose in human metabolism, glycosylation and congenital metabolic ...
2021年8月1日 · Galactosylated glycoconjugates, such as glycoproteins, keratan sulfate-containing proteoglycans and glycolipids, exert a plethora of biological functions, including structural support, cellular adhesion, intracellular signaling and many more.
Galactosylated chitosan-modified ethosomes combined with …
2020年11月10日 · In this study, we report a galactosylated ethosome (Eth-HA-GC) that has the ability to target DCs and stimulate them to mature. A novel SF nanofibrous mats loading Eth-HA-GC (Eth-HA-GC/SF) fabricated via green electrospinning shows a good performance in transdermal delivery of macromolecular antigens.
Galactosylation variations in marketed therapeutic antibodies
The G0 content in MAb1, MAb2 and MAb3 varies from 35% to 45%. However, the G0 content of MAb4, MAb5 and MAb6 varied from ~62% to ~83%. Based on these data, it appears that CHO cell-derived rIgGs are less galactosylated and contain higher amounts of G0 glycans compared with the rIgGs produced in mouse myeloma cells.
Structures of agalactosylated (G0), monogalactosylated (G1 ...
As expected, di-galactosylated glycan structures (lacking sialic acid) found on IgG-Fc differentiated LTBI from ATB, but also discriminated txATB from ATB.
Galactose: A Versatile Vector Unveiling the Potentials in Drug
2024年2月27日 · The use of galactosylated prodrugs has emerged as a highly effective strategy for improving the therapeutic potential of nonsteroidal anti-inflammatory drugs (NSAIDs), which are extensively utilized worldwide.
Production of galactosylated complex-type N-glycans in
2021年12月15日 · We produced galactosylated complex-type and hybrid-like N-glycans by expressing a human galactosyltransferase fusion protein both with and without a UDP-glucose 4-epimerase domain from Schizosaccharomyces pombe.
Galactosylated PLGA nanoparticles for the oral delivery of …
2018年7月13日 · In this study, we developed a galactosylated PLGA NPs (GNPs) to orally deliver RES, aiming to enhance the oral bioavailability and in vitro anti-inflammatory effect. Galactosylation was achieved through surface engineering of NPs by introducing N -oleoyl- d -galactosamine into the formulation.
Immobilized enzyme cascade for targeted glycosylation
2024年2月6日 · Immobilized β-1,4-galactosyltransferase is used to enhance the galactosylation profile of three IgGs, yielding 80.2–96.3% terminal galactosylation. Enzyme recycling is demonstrated for a reaction...
Galactosylated Liposomes for Targeted Co-Delivery of …
2016年7月30日 · The synergistic or combined effects by co-delivering anti-cancer drugs and siRNAs have also confirmed that Gal-DOX/siRNA-Ls had stronger tumor growth inhibition activity than DOX/siRNA-Ls and free DOX. This novel galactosylated liposome for co-delivery will enable its use as a targeted carrier against hepatic tumor.