The SARS-CoV-2 nucleocapsid protein is dynamic, disordered
2021年3月29日 · The nucleocapsid (N) protein from SARS-CoV-2 is a multivalent RNA-binding protein critical for viral replication and genome packaging 11,12. To better understand how the various folded and ...
Coronavirus nucleocapsid protein - Wikipedia
The nucleocapsid (N) protein is a protein that packages the positive-sense RNA genome of coronaviruses to form ribonucleoprotein structures enclosed within the viral capsid. [2] [3] The N protein is the most highly expressed of the four major coronavirus structural proteins. [2]
科学网—病毒结构小常识：衣壳和核衣壳 - 严家新的博文
2022年3月28日 · 病毒学中使学生感到困惑的一个问题是关于衣壳（capsids）和核衣壳（nucleocapsids）的概念。 这两个术语描述了病毒核酸和蛋白质在病毒颗粒中的两种不同排列方式。 衣壳(来自拉丁词capsa，原意box－盒子)是核酸基因组周围的蛋白质外壳（shell）。 下图是两种不同类型的衣壳，分别具有螺旋(左)和二十面体对称结构。 在这两种情况下，核酸都被蛋白质外壳所覆盖： 核衣壳的定义是病毒颗粒内的核酸-蛋白质组合。 当组合是病毒颗粒中的一个分 …
The SARS-CoV-2 nucleocapsid protein: its role in the viral life …
2023年1月10日 · Here, we summarize the latest research of the N protein, including its role in the SARS-CoV-2 life cycle, structure and function, and post-translational modifications in addition to its involvement in liquid–liquid phase separation (LLPS) and use as a basis for the development of vaccines and diagnostic techniques.
The Nucleocapsid Protein of the SARS Coronavirus: Structure, …
Nucleocapsid protein is the major constituent of a viral nucleocapsid. It is capable of associating with itself and with the genome, thus packaging the genome inside a closed cavity. In some viruses, nucleocapsid protein may also be assisted by other viral cofactors to form the capsid.
Structures of the SARS‐CoV‐2 nucleocapsid and their …
2020年9月11日 · Nucleocapsid (N) protein, which is the major structural component of the virion and is involved in viral replication, assembly and immune regulation, plays key roles in the viral life cycle. Here, we solved the crystal structures of the N‐ and C‐terminal domains (N‐ NTD and N‐ CTD ) of SARS ‐CoV‐2 N protein, at 1.8 and 1.5 Å ...
The SARS-CoV-2 Nucleocapsid Protein and Its Role in Viral …
Like other coronaviruses, the nucleocapsid (N) protein is one of the most crucial structural components of SARS-CoV-2. This protein shares 90% homology with the severe acute respiratory syndrome coronavirus N protein, implying functional significance.
The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually …
2021年1月21日 · The multifunctional nucleocapsid (N) protein in SARS-CoV-2 binds the ~30 kb viral RNA genome to aid its packaging into the 80–90 nm membrane-enveloped virion. The N protein is composed of...
The Coronavirus Nucleocapsid Is a Multifunctional Protein
The coronavirus nucleocapsid (N) is a structural protein that forms complexes with genomic RNA, interacts with the viral membrane protein during virion assembly and plays a critical role in enhancing the efficiency of virus transcription and assembly. Recent studies have confirmed that N is a multifunctional protein.
衣壳 - 维基百科，自由的百科全书
核壳蛋白 （nucleocapsid (N) protein）或 核衣壳蛋白，则是病毒核壳的主要蛋白质，其具有 核蛋白 性质，且能与核酸结合，起保护核酸的作用。 衣壳的类型大致是按它们的形态来分类的。 不同的病毒可以具有不同形态的衣壳，大多数病毒的衣壳为二十面体形和螺旋形。 但也有少量病毒，如 噬菌体 的衣壳具有较为复杂的结构，其衣壳类型为复合型。 [1] 二十面体形：二十面体形衣壳是由二十个三角形面组成的接近于球状的结构，如 腺病毒。 二十面体呈现5-3-2对称，即每个顶点 …