Cytokine release syndrome (CRS) - UpToDate
Immune effector cell-associated neurotoxicity syndrome (ICANS) is a neuropsychiatric syndrome that can occur in some patients who are treated with immunotherapy, which may or may not accompany CRS. This topic discusses the clinical presentation, diagnosis, …
Cytokine Release Syndrome (CRS) - Cleveland Clinic
Apr 7, 2022 · Cytokine release syndrome (CRS) happens when your immune system responds to infection or immunotherapy drugs more aggressively than it should. CRS symptoms include fever, nausea, fatigue and body aches. Prompt treatment is essential, as symptoms can worsen quickly.
Cytokine Release Syndrome: What It Is, Symptoms & Treatment
Nov 1, 2023 · Cytokine release syndrome may occur as a reaction to immunotherapy drugs for cancer. Learn the causes, risk factors, symptoms and treatment for CRS.
Management of Cytokine Release Syndrome (CRS) and HLH
Feb 7, 2022 · CRS symptoms and laboratory findings closely mimic infection; therefore, infectious workup and treatment are of primary importance. Other relevant differential diagnoses include tumour lysis and progression of the underlying malignancy.
Cytokine Release Syndrome (CRS): An In-Depth Guide for Clinicians
Characterized by an overproduction of pro-inflammatory cytokines, CRS requires timely diagnosis and intervention to prevent severe complications, including multi-organ failure. Understanding the underlying mechanisms, identifying biomarkers, and following treatment protocols are essential for effective CRS management.
Cytokine Release Syndrome (CRS) After Immunotherapy
Cytokine release syndrome (CRS) is a collection of symptoms that can develop as a side effect of certain types of immunotherapy, especially those which involve T-cells. The syndrome occurs when immune cells are activated and release large amounts of cytokines into the body.
Identification of cytokine release syndrome and indicators of …
Nov 4, 2024 · With the recent introduction of CRS diagnostic coding in retrospective data, this study aimed to measure the performance of the Keating algorithm to identify cases of any CRS and high‐grade (grade ≥2) CRS among patients with a diagnosis of CRS per ICD‐10‐CM coding.
Cytokine Release Syndrome (CRS) - International Myeloma …
Jun 19, 2024 · CRS is a recognized complication of certain T-cell-engaging (TCE) immunotherapies, such as CAR T-cell and bispecific therapy, and can occur with a severe infection, such as COVID-19. Prompt diagnosis and management of CRS are essential to prevent serious complications and improve patient outcomes.
Cytokine release syndrome - PMC
CRS can present with a variety of symptoms ranging from mild, flu-like symptoms to severe life-threatening manifestations of the overshooting inflammatory response (Fig. 1). Mild symptoms of CRS include fever, fatigue, headache, rash, arthralgia, and myalgia.
Cytokine Release Syndrome (CRS): An exaggerated systemic inflammatory response triggered by the effects of T-cell engaging therapies like BsAbs that cause release of inflammatory cytokines. CRS symptoms range from mild flu-like symptoms to severe multi-organ failure.