Chalcone - Wikipedia
网页Chalcone is the organic compound C 6 H 5 C(O)CH=CHC 6 H 5. It is an α,β-unsaturated ketone. A variety of important biological compounds are known collectively as chalcones or chalconoids. [3] They are widely known bioactive substances, fluorescent materials, and chemical intermediates.
Chalcone synthesis, properties and medicinal applications: a …
网页2020年1月6日 · Chalcone is an aromatic ketone that forms the central core of many important biological compounds, which are known as chalcones. Chalcones are the biogenetic precursors of flavonoids and isoflavonoids, which are abundant in plants.
Chalcone | C15H12O | CID 637760 - PubChem
网页Chalcone | C15H12O | CID 637760 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Chalcones: Synthetic Chemistry Follows Where Nature Leads
网页2021年8月13日 · Chalcone derivatives with 4-methylamino-ethanol functionality appeared to be the most potent ones. Most recently, a synthetic chalcone (139) (Figure 13) was demonstrated to possess antioxidant, anti-inflammatory, and neuroprotective properties . This chalcone could attenuate LPS-induced inflammation in RAW 264.7 macrophages.
Chalcone Scaffolds, Bioprecursors of Flavonoids: Chemistry ...
网页2021年11月26日 · Chalcone or chalconoid is an enone and an aromatic ketone, which forms the central core for several important biological compounds. Benzylideneacetophenone is the parent member of the chalcone series.
Chalcone: A Privileged Structure in Medicinal Chemistry
网页2017年5月10日 · Privileged structures have been widely used as an effective template in medicinal chemistry for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring compounds. Many chalcone derivatives have also been prepared due to their convenient synthesis.
Pharmacotherapeutics Applications and Chemistry of Chalcone …
网页2022年10月19日 · Chalcone derivatives potentially inhibit the different targets pathway of microbial resistance. Several chalcone compounds demonstrated optimum characteristics of an effective antimicrobial agent. However, their potential must be warranted using preclinical and clinical studies.
Chalcones - SpringerLink
网页2023年7月26日 · The synthesis occurs through a series of enzymatic reactions in the phenylpropanoid and flavonoid biosynthetic pathways. The key enzyme involved in chalcone synthesis is chalcone synthase (CHS), which catalyzes the first committed step of …
Chalcones: Diverse biological activities and structure–activity ...
网页2023年1月1日 · Chalcone is a chemical structure widely available in nature. Based on its broad-spectrum activities, chalcone is often used as a privileged scaffold in molecular design strategies to expand the accessible drug chemical space and support more successful drug development programs.
Chalcones: Synthetic Chemistry Follows Where Nature Leads
网页2021年8月13日 · This review article aims to demonstrate how bioinspired synthesis of chalcone derivatives can potentially introduce a new chemical space for exploitation for new drug discovery, justifying the title of this article.