Crotonyl-CoA - Wikipedia
Crotonyl-CoA - Wikipedia. Crotonyl-coenzyme A is an intermediate in the fermentation of butyric acid, and in the metabolism of lysine and tryptophan. [1] . It is important in the metabolism of fatty acids and amino acids. [2] Crotonyl-coA and reductases.
Protein lysine crotonylation: past, present, perspective
2021年7月14日 · Lysine crotonylation has been discovered in histone and non-histone proteins and found to be involved in diverse diseases and biological processes, such as neuropsychiatric disease,...
The mechanisms, regulations, and functions of histone lysine ...
2024年2月8日 · The chromodomain Y-like transcription co-repressor CDYL is a crotonyl-CoA hydratase that regulates the conversion of crotonyl-CoA to β-hydroxybutyryl-CoA and negatively adjusts histone Kcr.
Crotonylation of key metabolic enzymes regulates carbon …
2020年4月24日 · The short-chain acyl-CoA species, such as acetyl-CoA, malonyl-CoA, and succinyl-CoA, are catabolites from primary metabolism. Meanwhile, they are common precursors and building blocks for...
The Regulation and Function of Histone Crotonylation
2021年4月6日 · The donor for histone crotonylation, crotonyl-CoA, is an important intermediate involved in several cellular metabolic pathways including fatty acid and amino acid metabolism. The synthesis of crotonyl-CoA can also occur in the mitochondria or the cytoplasm.
Crotonylation and disease: Current progress and future …
2023年9月1日 · Crotonyl-CoA is an intermediate metabolite derived from fatty acid metabolism, either from crotonic acid catalyzed by Acyl-CoA synthetase short chain family member 2 (ACSS2) or through the oxidative degradation of lysine, tryptophan, and butyrate [2].
Crotonyl-CoA - an overview | ScienceDirect Topics
At least two routes can be used to generate (2S)-ethylmalonyl-CoA in Streptomyces (Figure 1d). One route involves reduction of crotonyl-CoA to (2S)-ethylmalonyl-CoA, by crotonyl-CoA carboxylase/reductase. Crotonyl-CoA comes from the acetoacetyl-CoA pathway, or from β -oxidation of even-chain fatty acids [41].
crotonoyl-CoA | C25H40N7O17P3S | CID 5497143 - PubChem
Description. Crotonoyl-CoA is the (E)-isomer of but-2-enoyl-CoA. It is functionally related to a crotonic acid. It is a conjugate acid of a crotonoyl-CoA (4-). ChEBI. Crotonoyl-CoA is a metabolite found in or produced by Escherichia coli (strain K12, MG1655).
Crotonyl-CoA - an overview | ScienceDirect Topics
In addition to writers, erasers, and readers, crotonyl-CoA, the substrate for Kcr, is a major factor influencing Kcr levels. Thus, the enzymes that can regulate the production and degradation of crotonyl-CoA are also the regulatory factors of Kcr, including ACSS2, chromodomain Y-like (CDYL), short-chain enoyl-CoA hydratase 1 (ECHS1), glutaryl ...
Intracellular crotonyl-CoA stimulates transcription through p300 ...
2015年4月16日 · In a cell-based model of transcriptional activation, increasing or decreasing the cellular concentration of crotonyl-CoA leads to enhanced or diminished gene expression, respectively, which correlates with the levels of histone crotonylation flanking the regulatory elements of activated genes.