N-Nitrosodiethylamine - Wikipedia
N-Nitrosodiethylamine (NDEA) is an organic compound with the formula Et 2 NNO (Et = C 2 H 5). A member of the nitrosamines, it is a light-sensitive, volatile, clear yellow oil that is soluble in water, lipids, and other organic solvents. It has an amine or aromatic odor.
Diethylnitrosamine - an overview | ScienceDirect Topics
Main technical features (chemicals, rodent species/strains, and endpoint lesions) and cancer hallmarks/emerging characteristics involved in the pathogenesis of diethylnitrosamine (DEN)-based hepatocarcinogenesis models.
The Carcinogenic Agent Diethylnitrosamine Induces Early …
2019年2月16日 · Diethylnitrosamine (DENA) is one of the most significant hepatotoxicants and hepatocarcinogens. Amines are activated by reaction with nitrate, leading to N-nitrosamines under the acidic medium of stomach (Sadik et al., 2008; Janani et al., 2010).
Diethylnitrosamine (DEN)-induced carcinogenic liver injury in …
2015年4月5日 · Diethylnitrosamine. The toxic properties of various nitrosamines in animals and humans are well established. The parenteral or oral administration of the smallest quantities of diethylnitrosamine (DEN) or dimethylnitrosamine (DMN) results in severe liver damage.
Diethylnitrosamine Increases Proliferation in Early Stages of …
2018年4月23日 · Diethylnitrosamine (DEN) induces hepatocarcinogenesis, increasing mitotic hepatocytes and leading to chronic inflammation. In addition, type 1 diabetes mellitus (T1DM) is also characterized by a proinflammatory state and by requiring insulin exogenous treatment.
Mouse models of hepatocellular carcinoma: an overview and …
2018年6月14日 · Diethylnitrosamine (DEN) is a carcinogen that has been used to induce HCC in mice for several decades, showing progression of disease from basophilic foci, hyperplasic nodules, hepatocellular ...
N-Nitrosodiethylamine | C4H10N2O | CID 5921 - PubChem
N-Nitrosodiethylamine | C4H10N2O | CID 5921 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Diethylnitrosamine - an overview | ScienceDirect Topics
Diethylnitrosamine (DEN) is a widely occurring carcinogen in nature. It is a drug with hepatotoxicity, cytotoxicity, and immunotoxicity, and is carcinogenic to both humans and animals. Oral ingestion may cause serious liver damage [48].
Diethylnitrosamine (DEN) induces irreversible hepatocellular ...
2009年12月15日 · Diethylnitrosamine (DEN) is a representative chemical carcinogen with the potential to cause tumors in various organs, including the liver, skin, gastrointestinal tract, and respiratory system. Specifically in HCC, DEN is a complete carcinogen.
Curcumae Ameliorates Diethylnitrosamine-Induced Hepatocellular ...
2021年10月27日 · In the current experimental study, we scrutinized the chemoprotective effect of curcumae against the diethylnitrosamine (DEN)-induced and high-fat diet (HFD)-promoted HCC development in the rats. Additionally, we investigated the preventive effect of curcumae on the gut microbiome in the HFD-promoted hepatic cancer model.