EZH2 - Wikipedia
Enhancer of zeste homolog 2 (EZH2) is a histone-lysine N-methyltransferase enzyme (EC 2.1.1.43) encoded by EZH2 gene, that participates in histone methylation and, ultimately, transcriptional repression. [5]
EZH2: a novel target for cancer treatment | Journal of Hematology ...
2020年7月28日 · Enhancer of zeste homolog 2 (EZH2) is enzymatic catalytic subunit of polycomb repressive complex 2 (PRC2) that can alter downstream target genes expression by trimethylation of Lys-27 in histone 3 (H3K27me3). EZH2 could also …
EZH2 Gene - GeneCards | EZH2 Protein | EZH2 Antibody
5 天之前 · EZH2 (Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit) is a Protein Coding gene. Diseases associated with EZH2 include Weaver Syndrome and Prc-2 Complex-Related Overgrowth Spectrum. Among its related pathways are RNA Polymerase I Promoter Opening and PIP3 activates AKT signaling.
Targeting EZH2 in Cancer: Mechanisms, Pathways, and …
2024年11月14日 · This review summarizes some of the mechanisms through which EZH2 regulates the expression and function of tumor suppressor genes and oncogenic molecules such as STAT3, mutant p53, and c-Myc and how it modulates the anti-cancer immune response.
EZH2 gene - MedlinePlus
The EZH2 gene provides instructions for making a type of enzyme called a histone methyltransferase. Histone methyltransferases modify proteins called histones, which are structural proteins that attach (bind) to DNA and give chromosomes their shape.
The roles of EZH2 in cancer and its inhibitors | Medical Oncology
2023年5月6日 · EZH2 is involved in the cell cycle, DNA damage repair, cell differentiation, autophagy, apoptosis, and immunological modulation. The main function of EZH2 is to catalyze the methylation of H3 histone of H3K27Me3, which inhibits the transcription of target genes, such as tumor suppressor genes.
EZH2 enzyme drives aggressive tumor growth in treatment …
2024年11月20日 · An enzyme called EZH2 has an unexpected role in driving aggressive tumor growth in treatment-resistant prostate cancers, according to a new study by scientists at Weill Cornell Medicine.
EZH2 in hepatocellular carcinoma: progression, immunity, and …
2023年6月2日 · Recent studies show that EZH2 is widely involved in proliferation and metastasis of HCC cells. In this review, the functions of EZH2 in HCC progression, the role of EZH2 in tumor immunity and the application of EZH2-related inhibitors in HCC therapy are summarized.
EZH2 Enzyme Linked to Drug Resistance and Tumor Growth in …
2024年11月20日 · Researchers at Weill Cornell Medicine have uncovered a surprising role for the enzyme EZH2 in driving aggressive tumor growth in prostate cancers resistant to treatment.
EZH2 : A Critical Competing Endogenous RNA in Cancer Research
2024年4月22日 · Enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) is one of these RNAs that has been identified as a potential therapeutic target in many types of cancer. Up to now, many studies have been conducted to elucidate ceRNA role of EZH2 in cancer.