Mammalian Germ Cell Development: From Mechanism to In …
In this article, Saitou provides a brief overview of key investigations, including those exploring the mechanism of mammalian germ cell specification and epigenetic reprogramming, that have established mammalian in vitro gametogenesis research, which has potential for innovating germ cell biology and reproductive medicine.
Genetics of germ cell development | Nature Reviews Genetics
2012年10月9日 · Germ cells are specialized cells that are responsible for transmitting the genome of an individual organism to its offspring. The defining characteristic of the germ cells is their...
Dispatch Germ cell development: Anchoring and pulling forces …
2024年12月16日 · In germ cell development, embryonic primordial germ cells migrate to the developing gonads, where they give rise to differentiating oocytes and spermatocytes. The developmental transition from migrating germ cells to their differentiation into oogonia in the ovary has long been a ‘black box’ in reproductive biology.
Phase Separation in Germ Cells and Development - Cell Press
How germ cells develop, function, and eventually give rise to entirely new organisms is an important question in biology. A growing body of evidence suggests that phase separation events likely play a significant and multifaceted role in germ cells and development.
Mammalian Germ Cell Development: From Mechanism to In …
2021年4月13日 · The germ cell lineage gives rise to totipotency and perpetuates and diversifies genetic as well as epigenetic information. Specifically, germ cells undergo epigenetic reprogramming/programming, replicate genetic information with high fidelity, and create genetic diversity through meiotic recombinati …
Human Germline Cell Development: from the Perspective of Single-Cell ...
2019年10月17日 · In this review, we discuss progress in analyzing the development of human germline cells, including preimplantation and implantation embryos, fetal germ cells (FGCs), and adult spermatogenesis by single-cell transcriptome and epigenome sequencing technologies.
Models of germ cell development and their application for …
Indeed, these models allow (1) examination of stages of germ cell development that are not easily accessible in mammals (specifically early development of the female germline), (2) the investigation of germ cell toxicity on a large-scale, high-throughput platform and (3) the easy mechanistic dissection of altered processes that are ...
Phase Separation in Germ Cells and Development - ScienceDirect
2020年10月2日 · How germ cells develop, function, and eventually give rise to entirely new organisms is an important question in biology. A growing body of evidence suggests that phase separation events likely play a significant and multifaceted role in germ cells and development.
Germ cell determination and the developmental origin of germ cell ...
2021年4月16日 · We compare germline development across diverse species to consider when and how determined (committed) germ cells are first distinguished from their germline precursors. We conclude that germ cell determination occurs late in development, after the body plan has been established and organogenesis begun, through a transition widely conserved ...
Germline development - Wikipedia
The germ plasm effectively turns off gene expression to render the genome of the cell inert. Cells expressing germ plasm become primordial germ cells (PGCs) which will then give rise to the gametes. The germ line development in mammals, on the other hand, occurs by induction and not by an endogenous germ plasm. [citation needed]