Accelerated mitochondrial dynamics promote spermatogonial ...
2024年11月12日 · Taken together, our findings unveil how proper spermatogonial differentiation is precisely controlled by concurrently accelerated and properly balanced mitochondrial fusion and fission in a germ cell stage-specific manner, thereby providing critical insights about mitochondrial contribution to stem cell fate decision.
Speed of germination — GermSpeed • germinationmetrics
Speed of germination expresses the rate of germination in terms of the total number of seeds that germinate in a time interval. Higher values indicate greater and faster germination. This is useful for comparisons only when samples or treatments possess similar germinabilities.
Mitochondrial fission regulates germ cell differentiation by ...
2019年12月23日 · Here we show that fission of the mitochondrial network is required to suppress increases in reactive oxygen species (ROS) levels; elevation of ROS in germ cells leads to the activation of EGFR signaling in adjacent cyst cells, resulting in loss of GSCs and early spermatogonia due to premature differentiation.
Aging shifts mitochondrial dynamics toward fission to promote …
Importantly, maintenance of aging GSCs can be enhanced by suppressing Drp1 expression to prevent mitochondrial fission or treating with rapamycin, which is known to promote autophagy via TOR inhibition.
A Germline‐Specific Regulator of Mitochondrial Fusion is Required …
2022年10月18日 · As seen in Figure 2J,K, both ovary and testis exhibited high expression of pld6, which expression signals were colocalized with vasa signals, which specifically labeled germ cells. Thus, we identified pld6 , a gene encoding mitochondrial fusion regulator, as a novel marker for zebrafish germ cells in both sexes.
Phase Separation in Germ Cells and Development - Cell Press
Because germ cell condensates are well studied, diverse, and cell-type specific, they serve as excellent model systems for studying phase separation in the context of development. We examine how germ cell condensates assemble, disassemble, and change properties in response to developmental cues.
Wake-up alarm: virtual time-lapse gene expression landscape
2021年3月29日 · After 6 h, spores swell (expansion growth) and by 8 h extend a protrusion, called germ projection or germ tube (Fig. 1). The outgrowth of a germ projection is a landmark for "wake-up" of spores that can be easily detected under standard light microscopes, and this process (or processes leading up to it) is often called “germination”, in a ...
Phase Separation in Germ Cells and Development - ScienceDirect
2020年10月2日 · Because germ cell condensates are well studied, diverse, and cell-type specific, they serve as excellent model systems for studying phase separation in the context of development. We examine how germ cell condensates assemble, disassemble, and change properties in response to developmental cues.
Epigenetic dynamics during germline development: insights from
2023年2月1日 · Gametogenesis produces the only cell type within a metazoan that contributes both genetic and epigenetic information to the offspring. Extensive epigenetic dynamics are required to express or repress gene expression in a precise spatiotemporal manner.
Phase Separation during Germline Development - Cell Press
2021年1月14日 · Phase separation controls the assembly and segregation of germ granules that determine which embryonic cells become germ cells. Phase separation promotes the formation of the Balbiani body, a structure that stores organelles and RNAs during the prolonged prophase arrest of oocytes.